Combating Drug-Resistant Tuberculosis: Evaluating the Efficacy of Q203 and PBTZ169

EasyChair Preprint 11871

Abstract

This research investigates the efficacy of Q203 and PBTZ169, both individually and in combination, as potential therapeutic agents against drug-resistant strains of Mycobacterium tuberculosis (Mtb). Utilizing a comprehensive approach, the study encompasses in vitro evaluations through the checkerboard method, in vivo assessments in zebrafish infection models, and analyses of bacterial burden and survival curves. In the in vitro phase, the combination of Q203 and PBTZ169 exhibits a synergistic effect, disrupting the growth of drug-resistant Mtb strains. The study further extends its scope to zebrafish infection models, providing a holistic understanding of the therapeutic impact.

Keyphrases: PBTZ169, Q203, Tuberculosis

@booklet{EasyChair:11871,
  author    = {Kurez Oroy and Chen Li},
  title     = {Combating Drug-Resistant Tuberculosis: Evaluating the Efficacy of Q203 and PBTZ169},
  howpublished = {EasyChair Preprint 11871},
  year      = {EasyChair, 2024}}