Download PDFOpen PDF in browserCracking the Code: Identifying Crucial Structural Features in Hsp90 Alpha Inhibitors for Effective Cancer TreatmentEasyChair Preprint 116316 pages•Date: December 27, 2023AbstractCancer remains a formidable health challenge, underscoring the urgency to devise innovative therapeutic strategies. Among the potential targets, Hsp90 Alpha emerges as a promising candidate due to its pivotal role in stabilizing several cancer-associated proteins. This research delves into the intricate structural features essential for inhibiting Hsp90 Alpha effectively. Employing consensus pharmacophore modeling, the study illuminates critical lipophilic and hydrogen-bonding domains within inhibitors that demonstrate heightened anti-cancer activity. Such insights pave the way for the development of potent and targeted anti-cancer therapeutics, heralding a promising stride in cancer treatment modalities. Keyphrases: Inhibitors, cancer, treatment
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