Potential of Graphene Oxide-Like Material Derived from Corn Cob Waste as Adsorbent Phase of Dispersive Solid Phase Extraction for Determination of Tetracycline Antibiotic Residue

EasyChair Preprint no. 10919

Abstract

The significant increase in the use of tetracycline antibiotics has become a new threat to human health. Antibiotics that are not absorbed will be excreted through feces and urine into the environment so that they can cause gene changes, hormonal disorders and cause antibiotic resistance. The low analyte concentration and complex matrix of antibiotic residues require appropriate sample preparation techniques. This study aims to investigate the potential of graphene oxide-like material derived from corncob for solid phase of dispersive solid phase extraction (DSPE) method as one of the sample preparation techniques. The production of graphene oxide was carried out using a single step method without an oxidizing agent. Characterization of graphene oxide was performed using FTIR instruments to determine functional groups, XRD to determine the level of crystallinity, and SEM-EDX to observe surface morphology and elemental composition. The optimum condition of DSPE method was conducted including variations in mass, pH, concentration, and contact time. The characterization results indicate that the synthesized graphene oxide possesses various functional groups, including oxygen, carboxyl, epoxy, carbonyl, and hydroxyl groups. Additionally, the material exhibits wrinkled surfaces and the X-ray diffraction analysis shows that the graphene oxide range typical for amorphous materials. The results showed that the optimum conditions were using single step graphene oxide at a mass of 8 mg with a concentration of 2 ppm at pH 5 and within 50 minutes. Based on this research, it can be inferred that graphene oxide-like material from corn cob waste show the high potential as solid phase od DSPE method for determination tetracyclic antibiotic residues with an absorption of 97%.

Keyphrases: Antibiotic, Corn cob, DSPE, Graphene oxide, Tetracycline

@Booklet{EasyChair:10919,
  author = {Rinawati and Ayu Miranda Umar and Buhani and Agung Abadi Kiswandono},
  title = {Potential of Graphene Oxide-Like Material Derived from Corn Cob Waste as Adsorbent Phase of Dispersive Solid Phase Extraction for Determination of Tetracycline Antibiotic Residue},
  howpublished = {EasyChair Preprint no. 10919},

  year = {EasyChair, 2023}}