Download PDFOpen PDF in browserNatural Products and Drug DiscoveryEasyChair Preprint 1504215 pages•Date: September 24, 2024AbstractNatural products have long been a rich source of therapeutic agents, playing a pivotal role in drug discovery and development. Their diverse chemical structures and biological activities offer unique opportunities for the identification of novel drug candidates. This review explores the contributions of natural products to modern drug discovery, highlighting their role in the identification of new drug targets and the development of innovative treatments for various diseases. We discuss key examples of natural products that have led to the development of successful drugs, including antibiotics, anticancer agents, and anti-inflammatory compounds. Additionally, advancements in technologies such as high-throughput screening, synthetic biology, and computational approaches are examined for their impact on the discovery and optimization of natural product-based drugs. The challenges and future directions in harnessing natural products for drug discovery are also addressed, emphasizing the need for continued research and collaboration between natural product chemists, biologists, and pharmacologists to unlock the full potential of these valuable compounds. Keyphrases: BET, Bromodomain, Epigenetics, cancer, dual inhibitor, inhibitor, kinase
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