Download PDFOpen PDF in browserRCT Simulations for Enhanced Tuberculosis Clinical Trial DesignEasyChair Preprint 119816 pages•Date: February 7, 2024AbstractClinical trials, pivotal for evaluating medical interventions, are undergoing a shift with Clinical Trial Simulation (CTS). CTS optimizes trial design, providing a cost-effective, evidence-based approach to drug development and intervention testing. The primary objective of this study is to use the power of simulations to evaluate the effectiveness of behavioral interventions, specifically addressing alcohol, depression, and tobacco as risk factors, in enhancing tuberculosis treatment outcomes. Implementing a robust power analysis framework and introducing the concept of “resimulations”, our study enhances statistical rigor and reliability across various intervention scenarios. This offers a versatile approach applicable to diverse research areas, providing a comprehensive framework to design and simulate Randomized Controlled Trials (RCTs), enabling reliable robust clinical studies. Keyphrases: Biostatistics, Comorbidity, Intervention Testing, Sample Size Optimization, Statistical Power Analysis, Tuberculosis, clinical trial design, randomized controlled trials, simulations
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